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Under President Bidens Cancer Moonshot Initiative, which aims to reduce cancer death rates by at least 50% over the next 25 years, there have been three major announcements about tobacco industry regulation in recent weeks

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Several studies have shown that smoking can contribute to many hair problems, including thinning, breakage, and even baldness

A valid-PRS established based on such a process thus fulfils the definition of an instrumental variable mentioned above if it remains associated with the designated phenotype of interest