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The latter human costs are thought to be intangible (they are derived from estimates of the value attached to a reduction in the quality of life in the event of illness, the consequences of death, etc.) and are generally no longer considered in cost estimates related to smoking

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Fortunately, recent efforts have already begun to characterize the population history of this region, inferring population split times between low- and high-elevation populations in the Andes, as well as the severity of the population size reduction associated with European contact (Lindo et al

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