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Description

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given to present collection, 2017

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L'encapsulation de l'AZTP peut tre optimise de la manire suivante : - Augmentation de la concentration de la solution de dpart en AZTPThe encapsulation of AZTP can be optimized in the following way: - Increase of the concentration of AZTP starting solution - Plusieurs cycles d'imprgnation- Several impregnation cycles - Diffrents temps d'imprgnation- Different impregnation times - Utilisation de solides modifis en surface avec PEG- Use of surface modified solids with PEG - Utilisation de diffrents solides avec une plus grande capacit (MILlOl biphenyl, MIL88D modifie avec diffrents groupes organiques) et de solides hybrides avec des ligands modifis (NH 2 , Cl, NO 2 , COOH, etc ) pour optimiser les interactions mdicament-solide- Use of different solids with greater capacity (MILlOl biphenyl, modified MIL88D with different organic groups) and hybrid solids with modified ligands (NH 2 , Cl, NO 2 , COOH, etc.) to optimize drug-solid interactions b) Encapsulation de I 1 AZTTP dans le nanoparticules de MIL-100 PEGyles ou nonb) Encapsulation of I 1 AZTTP in the nanoparticles of MIL-100 PEGylated or not Les nanoparticules du MIL-100 ont t synthtises par voie microondes (Microondes CEM) en partent d'une solution de 9,7 g de nitrate de fer hexahydrate (Aldrich, 97%), 3,38 g d'acide 1,3,5- benzenetricarboxylique (1,3,5-BTC, Aldrich, 99%) et 40 g d'eau distille 180 0 C pendant 30min (puissance 600W)

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