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The main pathological changes are found in the small airways with epithelial remodeling including goblet cell metaplasia, basal cell hyperplasia, leading to thickening of small airway walls and obliteration [4]

R., Ayres, P

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Lung cancer and lung diseases such as emphysema and chronic bronchitis Other types of cancers such as mouth, throat (pharynx), esophagus, larynx, bladder, pancreas, kidney, cervix, and some types of leukemia Heart and circulatory system problems, including heart attacks and strokes Diabetes, as smoking increases insulin resistance, which can set the stage for type 2 diabetes

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Reynolds has contended it is no longer responsible for making payments linked to the four brands