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Additionally, presynaptic dopamine released both subcortically and within the frontal regions of the brain are influenced by inhibitory GABA interneurons, therefore disruption in GABA signaling via NMDAR abnormalities has also been linked to abnormalities in dopamine signaling (73, 90, 91)

Identifying outliers in each dataset followed two steps

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Initially targeted at people trying to give up smoking, e-cigarettes have become increasingly popular, especially among younger users