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The confluence of pathogenic variants in FLG and STS in some patients may significantly increase the expressiveness of desquamation in RXLI patients and facilitate association of palmoplantar hyperlinearity.22 Autosomal recessive congenital ichthyosis (ARCI) ARCI alludes to its inheritance pattern, has a very low prevalence, estimated to be between 7.2 and 16.2 affected per million inhabitants both in Spain23 and other regions.24,25 Unlike ichthyoses in the previous group, ARCIs debut at birth

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