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Scientific evidence supporting reduced harm claims based solely on reduced exposure remains in.28 29 To prove that IQOS is safer than combustible cigarettes, PMI must show that IQOS significantly reduce[s] harm and the risk of tobacco-related disease to individual tobacco users and benefit[s] the health of the population as a whole taking into account both users of tobacco products and persons who do not currently use tobacco products'.68 Studies related to health effects range from lab-based smoking machine studies to assess constituent concentrations in products and aerosols/smoke

Proc Natl Acad Sci 104:1383313838

In total, 16 studies remained for the final analysis (Figure 1)