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In contrast, Veldheer et al

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Central nervous system effects of chronic toluene abuseClinical, brainstem evoked response and magnetic resonance imaging studies

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They can be formed by the thermal degradation of tobacco leaf constituents such as lignin and chlorogenic acid 71,72,80,81

To estimate the reliability of single measurements, the percentage AUC of all peaks greater than threefold of the CMSS measured during the post-combustion phase was calculated in five randomly selected cigarettes per brand