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Lancet (2012) 379:121424

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and 3) The genetic variant is not associated with confounders 26 (if the IV is correlated with other factors, the results may reflect the influence of the IV on the outcome through these factors rather than through the exposure, thereby weakening the interpretability of the findings and increasing the risk of misleading conclusions)

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Much of the available research for snuff and snus is on Swedish populations because the product was initially more available in Sweden