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The horizontal axis is linear in time, defined as the number of years between the midpoints of the participants period and the first period, and the vertical axis is logarithmic in serum cotinine concentration (ng/mL)

The American Lung Association warns that 69 of the over 7,000 chemicals released from a burned cigarette are carcinogenic, and a lot more are poisonous [4]

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This contrasts sharply with cigarette smoking, where the smoke is usually inhaled into the lungs, delivering nicotine more directly into the bloodstream