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Grossmann et al

The dose of NICOTROL NS, should be individualized on the basis of each patient's nicotine dependence and the occurrence of symptoms of nicotine excess (See Individualization of Dosage)

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Simulation exercise We next simulated the effects on consumption of cigarettes and bidis if the current excise tax was to be increased, using simulation models which have been used in a previous Indian study.20 The details of the simulation exercise are found in the online supplementary file and supplementary table S3

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Using an intracranial self-stimulation reward-based foraging task, we investigated in mice the impact of chronic nicotine on midbrain dopamine neuron activity and its consequence on the trade-off between exploitation and exploration