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Visceral involvement in HHT most commonly affects the lungs, liver, gastrointestinal tract, and brain, where arteriovenous malformations may lead to anemia, hypoxemia, stroke, cerebral abscess, or high-output cardiac failure

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During my years working in toxicology and regulatory science, one lesson became clear: demonstrating that an exposure causes a disease is far more complex than demonstrating that the two are associated

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