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When chronic bronchitis occurs together with decreased airflow it is known as chronic obstructive pulmonary disease (COPD)

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Sugiura T, Dohi Y, Hirowatari Y, Yamashita S, Ohte N, Kimura G, et al

Involvement of substrate analogs in the pathway could also lead to nicotine analogs as with 2- and 6-methylnicotinic acid in place of nicotinic acid leading to 2MN and 6MN, respectively

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