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Zaga V, Cattaruzza MS, Martucci P, Pacifici R, Trisolini R, et al

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Dedifferentiated RPE had globally decreased chromatin accessibility and expression of genes linked to hallmarks of aging. Notably, young, dedifferentiated RPE also exhibited a compensatory upregulation of hallmarks of aging-related genes including mitochondrial function and proteostasis while aged dedifferentiated RPE did not, which decreased their survival following CSC treatment, as experimentally verified with TUNEL labeling