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Acknowledgements This work was supported by the intramural WIR-grant of the Medical Faculty of the University of Duisburg-Essen granted to YH, G-EG, and JM, the PRO RETINA foundation to prevent blindness, Germany, granted to YH (Pro-Re/KP/Henning.09-2021), the European Unions Framework Program for Research and Innovation Horizon 2020 (2014-2020) under Marie Skodowska-Curie (Grant Agreements No