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Results showed that all eight clinical-risk endpoints improved in smokers who switched to IQOS by the end of the six-month study and that the majority of these endpoints (five of the eight) showed statistically significant differences between smokers who switched to IQOS compared with those who continued smoking

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At the week 12 visit the corresponding proportions were 19.6% in the snus group (31/158) versus 12.4% in the placebo group (20/161) for an estimated odds ratio of 1.7 (95% C.I.: 0.94-3.23, p = 0.08)

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In 2025, there was also an increase in the use of nicotine pouches across all age groups

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