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Coculturing nave CD4 + T cells isolated from the spleens of Gpr15 +/+ mice with CSE (0.251%) did not increase IFN- or IL-4 expression, indicating that CSE does not influence their differentiation into Th1 or Th2 cells (Supplementary Fig

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Furthermore, four participants, all with stationary time-series on either alcohol use, nicotine use, or both, reported use of other substances during the study period

Atrial fibrillation (AF) confers a major health care burden and has an overall prevalence of 1% to 2% in the general population, with even higher rates in older people