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These basic ingredients of tobacco smoke cause an increase in oxidative stress, endothelial damage and dysfunction, and are associated with significantly higher serum concentrations of total cholesterol and triglycerides, and lower levels of the cardioprotective high-density lipoprotein

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Further, we investigated the morphological changes in lungs of mice and found that the mean linear intercept in the lungs of mice exposed to smoke for 12 weeks is much larger than those exposed to room air, suggesting that tobacco smoke induced emphysema (Figure 5)