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This activation triggers intracellular signaling cascades including the extracellular signal-regulated kinase (ERK) pathway, which increases expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF)

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Most of these severe cases, so far, appear to be symptoms that can occur when either oils or lipid-containing substances enter lungs, says Scott Gottlieb, who recently stepped down as commissioner of the FDA

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