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Recent studies have demonstrated a link between hypoxia and sterile inflammation via IL-1 priming of the NLRP3 inflammasome [67,68,69,70,71]

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Camel in particular came under fire for its use of the character Joe Camel , a cartoon smoking camel who is said to have been an attempt to appeal to a young audience

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With relatively low cost, this measure significantly reduces tobacco use and the economic burden associated with smoking