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Two metabolites of progesterone are strongly related to cannabis consumption In the OPLS-DA model M1, the highest and third-highest VIP values were attributed to two progestogens, namely 5-dihydroprogesterone (5-DHP4) and 11-hydroxyprogesterone (11-OHP4), which were more concentrated in serum from cannabis consumers (see Fig

10.1038/nri978 [DOI] [PubMed] [Google Scholar] 18

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