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Farsalinos et al., 2018a

This condition is particularly prevalent among smokers due to: Salivary gland alterations from tobacco use Nicotines vasoconstrictive effects Chemical irritation from tobacco smoke The lack of saliva can lead to increased tooth decay, gum disease, and oral infections

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The fumaric acid released by degradation of the nanoparticles was quantified in the supernatant by reverse phase HPLC, thanks to a spectrophotometric detection ( = 210 nm)