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Acute water toxicity has been reported due to the rapid consumption of large quantities of fluids that greatly exceeded the kidney's maximal excretion rate of approximately 0.7 to 1.0 L/hour

A case-control study demonstrated impaired gastrointestinal absorption in 30% and decreased serum B12 levels in 6% of patients in the metformin arm compared to none in the control arm (Tomkin et al., 1971)

The smoking prevalence among men declined by only 6.9 percentage points during the 18 years (20052023), from 49.2% in 2006 to 42.3% in 2023.11 12 Evidence from 2018 to 2020 International Tobacco Control (ITC) Vietnam also confirmed that current cigarette prices were not sufficient to motivate cessation behaviours.13 Given that the Vietnamese government did not meet the 2020 target of reducing male smoking prevalence to 39.0% as outlined in the National Strategy on Tobacco Control, realigning tax policies so that they decrease affordability is critical in efforts to reduce smoking rates in Vietnam

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