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Many of those chemicals are poisonous and at least 69 of them are connected to cancer

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Centers for Disease Control and Prevention (US), Atlanta Zhu S-H, Lee M, Zhuang Y-L, Gamst A, Wolfson T (2012) Interventions to increase smoking cessation at the population level: how much progress has been made in the last two decades

The risk of contracting pancreatic cancer is now similar to that of someone who has never smoked

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Nicotine reduction revisited: science and future directions