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Beyond Pleasure: Aversion Pathways While the mesolimbic dopamine system mediates nicotines rewarding effects, nicotine also activates the medial habenulainterpeduncular nucleus (MHbIPN) circuit, which produces aversive sensations such as nausea at high doses

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Its not just the visible smoke you see curling into the air

Smoking has long been linked to serious health hazards, from respiratory issues to cardiovascular problems

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Both associations were rated as weak, with lung cancer receiving a two-star rating and breast cancer a one-star rating in the BPRF framework