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The most likely reason smoke detectors go off unexpectedly is that people arent changing the batteries often enough

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A 2021 risk assessment found that typical diacetyl exposure levels from e-cigarette use could result in hazard quotients up to 200300 times above safe limits, strongly suggesting a significant risk for irreversible small-airway fibrosis (bronchiolitis obliterans) among teen and adult vapers of diacetyl-containing flavors (11)

Wang S, Xu P, Tang H, Meng J, Liu X, Huang J, Chen H, Du Y, Blankespoor H (2004) Biodegradation and detoxification of nicotine in tobacco solid waste by a Pseudomonas sp