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ATRA is now widely used in preclinical and clinical studies and has shown great anticancer potential in phase II and III clinical trials in patients with various cancers [180]
In the United States, in the 1950s and 1960s, cigarette brands frequently sponsored television showsmost notably To Tell the Truth and Ive Got a Secret and popular TV shows such as and The Flintstones which were watched by many children and teens
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So, how does cigarette smoke affect the gastrointestinal system
Its well known that East Asians had higher proportion of genetic variant of the aldehyde dehydrogenase 2 (ALDH2) enzyme, identified as ALDH2*2, which cause lower metabolic efficiency of reactive aldehyde carcinogens 34
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