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In case of significant group differences, a potential confounding effect of tobacco exposure was addressed by performing MANCOVA (Multivariate Analyses of Covariance) with past year tobacco exposure as control variable, estimated WBC proportion per cell type / target gene methylation / target gene expression as dependent variables and group membership as the predictor variable, reporting F -values, p -values and partial eta squared ( 2 part ) for effect size estimations ( 2 part 0.01 was interpreted as small effect, 2 part 0.06 as a medium effect size and 2 part 0.14 as a strong effect [45])

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[8] The Warrant seal, which had previously been on the flip lid of the box, was removed