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FDA (2018), US Food and Drug Administration, Premarket Tobacco Product Applications and Recordkeeping Requirements. US Food and Drug Administration, Regulation and Enforcement of Non-Tobacco Nicotine (NTN) Products, November 6, 2023, Juul Labs, Juul Labs Statement on FDA Marketing Authorizations, press release, July 17, 2025,

Alcohol causes the most harm overall, with a cumulative weighted score of 79, the study, published in the Journal of Psychopharmacology, found

Drinking levels defined

Development of mental health disorders: There is research to suggest that abusing alcohol increases the risk of an individual developing post-traumatic stress disorder by hindering their ability to heal from traumatic experiences

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H., & Conrod, P